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Primer™ — Part 1

Primer™
Microbiomic Superfuel™

Gut Feelings
There are trillions of bacteria, living and breeding inside your body, right now. The gut and its microbiome are essentially a massive endocrine organ, controlling and influencing basically your entire body and brain. You need some of them to survive, but many of them hate you.

For most people, due to genetics and/or diet, the evil ones have gotten the upper hand, attacking you with not only fat gain, but whole body inflammation accompanied by damage to insulin sensitivity, cardiovascular and digestive health, the immune system, and even your skin and brain. And, given that all of these trillions of bacteria that call your gut “home” originally came from outside your body – and entered without your permission – it is by far the most important organ in which we can take steps to manipulate and regain control.

You have sought out and destroyed these invaders with Shock Therapy™, freeing the kingdom of your gut. You are repopulating it with loyal, benevolent bacterial citizens with SupraBiotic™. But, you must feed, protect, and nurture them.

Primer™ provides a gourmet buffet of prebiotic dishes specifically prepared to the needs and tastes of the most beneficial probiotic bacteria, along with the materials to rebuild, fortify, and make impregnable, the castle walls that are the intestinal barrier.

Deus Vult!

The Gut-Wrenching Truth

The Western lifestyle (including diet, lack of exercise, and alcohol use) leads to an imbalance of the bacterial composition of the gut. This results in the excess production of inflammatory signals, such as Lipopolysaccharide (LPS), which escape the gut and enter the rest of your body. This leads to general digestive issues and inflammatory bowel syndromes like IBS. While fixing digestive disorders will come along for the ride, our primary focus is going to be on body composition and metabolic health. In other words, we want to make you leaner, protect against diabetes, and help keep you from having a heart attack or stroke.

LPS causes an increase in digestion speed, which leads to less nutrient absorption and feedback signals that tell the brain that it is time to stop eating. But, in the colon, speed is decreased which results in a greater total utilization of caloric energy from your food.

In other words, your brain tells you to keep eating and this leads to excessive fat accumulation from harvesting more calories. This aggravates the cycle further, as overeating and increased adiposity are inflammatory. So, what you have is more inflammation, more dysfunction, greater food intake, greater extraction of food, more fat accumulation, and REPEAT!

The carnage does not end here. Along with this inflammatory state is a disruption in the intestinal barrier. Intestinal permeability is increased and these inflammatory agents spill out. This is often called a “leaky gut”. The biggest culprit here is, once again, LPS.

This goes in conjunction with decrease in activity of brake signals such as short chain fatty acids (SCFAs), PPAR-alpha, and AMPK that act as anti-inflammatories and protect intestinal barrier function.

Once LPS escapes, it is active in the body and brain, just as in the intestine. In the fat tissue, this leads to fat storage. In the brain, it increases appetite, hunger, and food intake. It does so by decreasing both insulin and leptin insensitivity, peripherally and centrally, via Toll-like Receptor-4 (TLR4). At this point, your body fat thermostat is wrecked, your ability to control food intake is gone, and you are a fat storing machine.

It is important to note, this low-level but constant systemic inflammation, PRECEDES insulin/leptin resistance and obesity. Elevated LPS levels, which occur during a Western-style and high-fat diet, initiate all of this.

More bad news: atherosclerosis, heart disease, and stroke are promoted by these same inflammatory pathways. Combined with the increased body fat and insulin resistance, you officially have the perfect ingredients for the dreaded Metabolic Syndrome.

Obviously, this is not what you want your body doing to itself. It is not what you want it doing to you. It is not what you want it doing to your life.

And, it is just a bunch of microscopic bacteria causing all of this devastation. They need to go.

Probiotically Speaking

The most well-known, commercial probiotics are Lactobacillus and Bifidobacterium. They are also among the most common in the body, along with several other really interesting ones which are not commercially available, but we can manipulate with supplementation as you will soon learn.

Unfortunately, Lactobacillus belong to the Firmicutes phylum which is associated with weight gain and obesity. Just a 20% increase in Firmicutes with an equal decrease in Bacteroides results in an increased energy harvest of 150 calories per day in humans. That is equal to 15lbs of fat per year! Modern food processing and the Western style diet promote these negative changes in microbial proportions. Thus, one can plainly see why it can be so difficult to get lean, as well as how easily obesity has become an epidemic.

In addition, probiotic treatment with several Lactobacillus species are directly associated with weight gain, body mass index, obesity, and Type-2 diabetes. They don’t tell you that on the label.

More powerful evidence of the profound effect of the microbiota on body weight and metabolism come from studies on fecal transfer. And, yes, that is exactly what it sounds like – transferring poop from one subject’s intestine to another’s. In twins, transfer of an obese microbiota to lean mice was accompanied by an increase in fat cell formation, fat storage, bodyweight, fat mass, feelings of hunger, food consumption, and a dysbiotic alteration of the Firmicutes:Bacteroides ratio to reflect that of the obese model. On the other side of the coin, transferring the intestinal microbiota from lean donors to obese does the opposite – it fixes all of these things. Obviously, while it highlights the science, doing a fecal transfer is not terribly practical, appetizing, or readily available.

Fortunately, there is good news. While several species and strains of lactobacillus have been found to promote weight gain, several have also been found to protect against it. And, of course, we only used the good ones. Furthermore, Bifidobacterium have shown only positive effects to a remarkable extent.

So, let’s get to it.

You may have noticed that almost no probiotic formulas contain just a single species of bacteria, nowadays. And, if you did not, I will just say that it is for a good reason. They work better in combination. Microbial diversity is good. Essentially, a diverse gut is a healthy gut. This applies to the prebiotics that feed them. You need a variety of prebiotics to grow a variety of probiotic bacterial species.

However, you do not to be randomly feeding every single species and strain inside of you. It needs to be done rationally. You want the good ones to gorge themselves, and the bad ones to have to go hungry.

Another benefit of prebiotic combinations is by providing precursors to promote cross-feeding. This is when fermentation by one bacterial strain produces metabolites that others use for fuel, as we will discuss in a bit.

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SupraBiotic™ Ingredients — Part 2

Pomegranate Extract

Extremely rich source of polyphenols

Polyphenols are generally prebiotic for good bacteria (Bifidobacterium, Akkermansia, Bacteroides, and Roseburia), and antibacterial for less favorable and pathogenic ones

Fruit/berry based polyphenols are particularly favorable toward Bacteroides, the Firmicutes:Bacteroides ratio, and Akkermansia

Akkermansia is increased 10 to 30-fold by various fruit polyphenols and by 33 to 47-fold with Pomegranate Extract

Reduces weight gain, fat storage, visceral and subcutaneous fat, as well as insulin resistance
Activates AMPK at 2 times the potency of metformin

Inhibits LPS and inflammation, enhancing tight junction protein integrity and intestinal barrier function

Lowers blood glucose output

Fermented Herbs
Fermentation of herbs results in much higher concentrations of active compounds compared to unfermented. This same fermentation is done in the body, but it is highly dependent upon the microbial make-up of the individual’s gut, so it can vary widely from person to person.

Fermented Kudzu

Polyphenol rich

Reduces body weight, body mass index, visceral and subcutaneous fat mass, and lipogenesis

Stimulates lipolysis, fatty acid oxidation, and thermogenesis

Potent anti-inflammatory, inhibits LPS and TLR-4, improving insulin sensitivity

Reduces intestinal permeability and improves intestinal barrier function

Fermented Ginseng

Decreases bodyweight, fat mass, adipocyte size, and food efficiency

Improves glucose uptake, as well as insulin and leptin sensitivity

All of these effects are superior with fermented vs. regular Ginseng

Decreases inflammatory cytokines and protects the intestinal barrier

Increases mucins (Akkermansia and Bacteroides food) by 50%

Strong prebiotic specificity toward Bifidobacterium and Bacteroides

Synergistic with prebiotics

Mulberry Extract

SupraBiotic™ contains an industry-best Mulberry Extract, standardized to over 5% 1-Deoxynojirimycin (1-DNJ) and containing relevant amounts of d-Fagomine, as well. Like all berries, it also has high polyphenol content, the benefits of which we have already talked about.

1-DNJ

Significantly lowers body weight, blood glucose, and serum insulin levels

Increases the insulin and leptin sensitizing peptide adiponectin (which activates AMPK)

Reduces visceral adipose tissue, adipose tissue mass, triglycerides, and lipid accumulation

Remarkably potent, elevating adiponectin, GLUT4, and AMPK with 1000 times the potency of metformin

Increased fatty acid oxidation, while improving mitochondrial function and lipid metabolism

Reduces glucose and insulin output

D-fagomine

Reduces weight gain, plasma triglycerides, and glucose

Attenuates fat gain on obesity promoting diet

Enhances leptin and insulin sensitivity

Lowers post-meal glucose levels

Selenium

Synergistic with probiotics, increasing microbial diversity

Enhances prebiotic fermentation activity by gut bacteria

Results in better probiotic bacterial growth as well as output of SCFAs

Queen’s Bee Acid (10-hydroxy-2-decenoic acid)

25 times as potent at AMPK as metformin

Increases GLUT4, glucose uptake, and insulin sensitivity

Inhibits LPS induced cytokine production

Enhances intestinal barrier function and tight junction assembly via AMPK

Improves LPS induced blood-brain-barrier disruption much as it does with the intestinal barrier

Improves central insulin and leptin signaling, keeping your body fat thermostat functioning properly

Palmitoylethanolamide (PEA)

Increase satiety via PPAR-alpha, reducing food intake and body weight

Decreases intestinal transit rate, prolonging its own activity on satiety

Increases endocannabinoid and PPAR-alpha levels, keeping LPS inflammation and obesity promoting activity in check

Selective inhibits insulin and leptin desensitizer TLR-4

Protects against Western style and high-fat diet induced disruptions of endocannabinoid control of gut-brain axis regulation of food intake and fat storage

Cannabinoid normalization increased Akkermansia by 4-fold, and improved the Firmicutes:Bacteroides ratio by 6-fold

Particularly useful with high-fat diets, including low carb

Ginger Extract (20% Gingerols)

Potent anti-inflammatory and antioxidant

Inhibits LPS induced inflammation

Activates PPAR-alpha, as well as AMPK, with 5 times the potency of metformin

Increases tight junction proteins and protects barrier integrity against inflammatory assault

Suppress colitis via anti-inflammatory and anti-oxidant activity

Enhances the survival and proliferation of intestinal epithelial cells

Reduces spasms of smooth muscle in the digestive tract

Increases uptake of Calcium (100+%) and Glutamic acid (60%), both of which protect intestinal barrier function

CONCLUSION
As you can see, SupraBiotic™ takes the concept of probiotic far beyond where anyone has previously taken it before. It starts with bacterial species carefully and purposefully selected to protect against dysfunction of the gut and microbiota to promote better health, better appetite control, better metabolism, and better fat loss. On top of this, SupraBiotic™ addresses and supports novel probiotic bacterial species that you cannot attain, anywhere, and does so in a way that no other product is even close to doing. Finally, its supporting ingredients crush inflammation and repair your leaky gut, leaving your body functioning in the optimal way it is intended to.

SupraBiotic™ is a one of a kind product that fits perfectly with and enhances any diet and exercise program, any supplement regimen, any lifestyle.

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SupraBiotic™ Ingredients — Science Preface

Short Chain Fatty Acids (SCFAs)

One of the primary ways that probiotic bacteria work their magic is by fermenting prebiotics and producing SCFAs (primarily acetate, butyrate, and propionate). Low carbohydrate diets can result in less fermentable material, thus lower SCFA levels, if you do not make a point to get adequate fiber. SCFAs primarily work by activating free fatty acid receptors, FFAR2 and FFRA3 and by decreasing inflammation and permeability in the gut.

Induction of FFA2/3 protects against obesity and insulin resistance by decreasing hunger and food intake, increasing energy expenditure, and improving glucose and lipid metabolism. Butyrate is also the preferred energy source, along with Glutamine, for maintenance and repair of epithelial cells in the colon. It increases tight junction assembly, thus improving barrier function, specifically through AMPK.

AMPK is basically the airbrakes on the runaway train of inflammation and “leaky gut” induced metabolic dysfunction caused by modern food processing, the Western diet, and microbial dysbiosis. In addition to its involvement in barrier function, AMPK activation is extremely positive for the great bacteria that we can’t get commercially. Its activation increases Akkermansia and Bacteroides levels, at least partially by elevating production of mucin, one of their favorite foods.

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SupraBiotic™ Ingredients — Part 1

SupraBiotic™ The Slimming Probiotic™ Ingredients

You may have noticed that almost no probiotic formulas contain just a single species of bacteria, nowadays. And, if you did not, I will just say that it is for a good reason. They work better in combination. Microbial diversity is good. Essentially, a diverse gut is a healthy gut.

However, you do not want to just throw every single commercially available species and strain into a product as so many companies do. They need to be rationally combined. If not, they can interfere with each other’s actions and compete for space and resources.

But, the most interesting benefit of probiotic combinations is through cross-feeding. This is when one bacterial strain produces metabolites the others use for fuel, as we will discuss in a bit.

Right now, let’s get to the SupraBiotic™ probiotic combination.

Bifidobacterium breve

Suppresses the accumulation of body weight and fat mass

Improves lipid metabolism and insulin/leptin sensitivity

Combats LPS induced inflammation and leaky gut

Inhibits enemy of leptin/insulin sensitivity Toll-like Receptor-4 (TLR-4) activity

Reinforces intestinal epithelial cells and mucosa, improving the physical barrier of the intestine

Bifidobacterium animalis subsp. lactis

Increases short chain fatty acid (SCFA) production to distal parts of the colon, meaning it has a long acting mechanism of action

Shifts the microbiota toward that of a lean phenotype

Negatively associated with body mass index and obesity

Reduces hunger, weight gain, fat mass accumulation and preserves glucose tolerance

Reverses inflammation induced insulin resistance

Improved the efficacy of AMPK agonist metformin, suggesting potentiation with this pathway

Reduces LPS and inflammation, preserving gut barrier function and recovery in response to stress

Lactobacillis plantarum

Higher in lean subjects

Inhibits weight gain, fat storage, fat cell formation, adipose cell size, and adipose tissue mass

Reduces plasma glucose, insulin, triglycerides, and oxidative stress levels

Increases fatty acid oxidation

Improves insulin and leptin sensitivity against an obesity promoting diet via up-regulation of PPAR-alpha

Increases in leptin levels even during weight loss

Preferentially directs calories toward lean tissue

Synergistic with other probiotics as well as with polyphenols

Increases levels of the genus Bacteroides while reducing the Firmicutes:Bacteroides ratio

Potent anti-inflammatory, attenuating signaling of LPS and TLR-4

Increased tight junction protein formation and improved intestinal barrier function

Lactobacillis gasseri

Mitigates bodyweight and fat mass increases in obesity promoting diets

Decreases both visceral and subcutaneous adipose tissue

Increases insulin and leptin sensitivity via adiponectin (which activates AMPK)

Elevates total energy expenditure

Increases tight-junction protein expression and improves intestinal barrier function

Inhibits LPS production, intestinal permeability, and adipose tissue inflammation

Lactobacillis rhamnosum

Reduces weight gain, fat mass, and fat synthesis

Increases Bacteroides and improves the obesity associated Firmicutes:Bacteroides ratio

Increases insulin and leptin sensitizing peptide adiponectin (which activates AMPK)

Raises leptin levels even with weight loss

Enhances fatty acid oxidation and insulin sensitivity via activation of AMPK in both adipose and skeletal muscle tissue

Upregulates thermogenesis

Decreases LPS and LPS induced systemic inflammatory markers, as well as TLR-4 expression

Protective of microbial composition, inflammation, tight junction proteins, and gut barrier function against a high fructose diet as well as alcohol

Anxiolytic in response to stress

Bifidobacterium adolescentis

Higher in lean than obese populations and levels predict leanness, in general

Reduces bodyweight, visceral adipose tissue, and fat mass, while improving insulin resistance

Synergistic with polyphenols

Most important as THE archetypal cross-feeder of several of the most important and impressive strains of bacteria

Produces acetate and oligosaccharides which are then consumed by acetate utilizing, butyrate and propionate producing bacteria — the ones that are not commercially available

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SupraBiotic™ — not actually Ingredients

The Best Probiotics That Money Can’t Buy

Unfortunately, several species of bacteria with some of the very best data are not available commercially, due to regulatory issues and well as practical challenges that will not soon be resolved.

Fortunately, there are a myriad of ways to specifically target and increase these strains using methods that ARE available. And, that is exactly what we have done. So, let’s take a look at these novel wonder-bacteria.

Genus Bacteroides

Bacteroides are butyrate and propionate producing. Levels were 6-fold higher in lean vs. obese subjects. It has a negative correlation with fat mass, waist circumference, and energy intake. Bacteroides levels in Type-2 diabetes were only half that of those with normal glucose tolerance. The Firmicutes:Bacteroides ratio was also significantly worse in obese patients, even in comparison with the merely overweight .

Various species in the Bacteroides genus reduced bodyweight and fat gain, triglycerides, and adipocyte volume while improving insulin and leptin sensitivity. It also lowered LPS and other inflammatory signals, while increasing fatty acid oxidation via PPAR-alpha.

Faecalibacterium prausnitzii

Faecalibacterium prausnitzii is butyrate producing and is considered a physiological sensor and marker of human health. It really does not get much more important than that. It is lower in the obese and type-2 diabetics, as well as higher in normal glucose tolerance vs. prediabetic subjects. It reduces inflammatory markers, improves intestinal barrier function, and is sharply decreased in various inflammatory bowel diseases.

Akkermansia muciniphilia

Akkermansia muciniphilia is mucin consuming and butyrate producing. Levels are higher in lean subjects than the general population and decreased in obesity and type-2 diabetes. This species is also inversely correlated to fasting glucose, waist-to-hip ratio, subcutaneous adipocyte diameter, plasma triglyceride levels, visceral adipose tissue mass, and insulin resistance.

Its administration reduced fat mass, adipose tissue inflammation, and enhanced insulin sensitivity. Akkermansia levels are higher in normal glucose tolerance vs. pre-diabetic subjects. It increases intestinal endocannabinoid levels, decreasing inflammatory cytokine production and protecting intestinal barrier function.

Roseburia Species

Roseburia species are butyrate producing. Increased levels are associated with decreased body weight, fat mass, insulin sensitivity, and triglycerides — independent of calorie intake. Higher Roseburia counts are correlated with reduced body weight, improved profile of lipid and obesity related gene expression, along with a normalized inflammatory status. It is also lower in type-2 diabetes and atherosclerosis.

Bifidobacterium adolescentis as Cross-Feeder

As mentioned, the most important contribution of B. adolescentis is to feed other bacteria, specifically the really good but unavailable ones above.

B. adolescentis is superior to other potential cross-feeding Bifidobacterium in that it provides a slow, steady degradation of oligosaccharides for a long, continuous release of substrate for these various bacteria to feed on. It is essentially time-released, allowing acetate feeding, butyrate producing bacteria to grow and thrive throughout the entire length of the gut.

Faecalibacterium prausnitzii is almost fully dependent on acetate, which B. adolescentis supplies. F. prausnitzii converts it to butyrate with 85% efficiency, and its growth is enhanced by co-culture with B. adolescentis. Roseburia also generally requires acetate for growth. B. adolescentis also increases Roseburia and F. prausnitzii via partial breakdown of prebiotic oligosaccharides and carbohydrates, which they can then feed on.

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SupraBiotic™ — Part 1

SupraBiotic™
The Slimming Probiotic™

Gut Feelings

There are trillions of bacteria, living and breeding inside your body, right now. The gut and its microbiome are essentially a massive endocrine organ, controlling and influencing basically your entire body and brain. You need some of them to survive, but many of them hate you.

For most people, due to genetics and/or diet, the evil ones have gotten the upper hand, attacking you with not only fat gain, but whole body inflammation accompanied by damage to insulin sensitivity, cardiovascular and digestive health, the immune system, and even your skin and brain. And, given that all of these trillions of bacteria that call your gut “home” originally came from outside your body – and entered without your permission – it is by far the most important organ in which we can take steps to manipulate and regain control.

SupraBiotic™ combines 6 probiotic strains, over 80 billion colony forming units, with an unrivalled auxiliary formula, optimized to turn the bacterial milieu of your gut into a mean, lean body machine.

You have sought out and destroyed these invaders with Shock Therapy™, freeing the kingdom of your gut. Now, repopulate it with loyal, benevolent bacterial citizens with SupraBiotic™
Deus Vult!

The Gut-Wrenching Truth

The Western lifestyle (including diet, lack of exercise, and alcohol use) leads to an imbalance of the bacterial composition of the gut. This results in the excess production of inflammatory signals, such as Lipopolysaccharide (LPS), which escape the gut and enter the rest of your body. This leads to general digestive issues and inflammatory bowel syndromes like IBS. While fixing digestive disorders will come along for the ride, our primary focus is going to be on body composition and metabolic health. In other words, we want to make you leaner, protect against diabetes, and help keep you from having a heart attack or stroke.

LPS causes an increase in digestion speed, which leads to less nutrient absorption and feedback signals that tell the brain that it is time to stop eating. But, in the colon, speed is decreased which results in a greater total utilization of caloric energy from your food.

In other words, your brain tells you to keep eating and this leads to excessive fat accumulation from harvesting more calories. This aggravates the cycle further, as overeating and increased adiposity are inflammatory. So, what you have is more inflammation, more dysfunction, greater food intake, greater extraction of food, more fat accumulation, and REPEAT!

The carnage does not end here. Along with this inflammatory state is a disruption in the intestinal barrier. Intestinal permeability is increased and these inflammatory agents spill out. This is often called a “leaky gut”. The biggest culprit here is, once again, LPS.

This goes in conjunction with decrease in activity of brake signals such as short chain fatty acids (SCFAs), PPAR-alpha, and AMPK that act as anti-inflammatories and protect intestinal barrier function.

Once LPS escapes, it is active in the body and brain, just as in the intestine. In the fat tissue, this leads to fat storage. In the brain, it increases appetite, hunger, and food intake. It does so by decreasing both insulin and leptin insensitivity, peripherally and centrally, via Toll-like Receptor-4 (TLR4). At this point, your body fat thermostat is wrecked, your ability to control food intake is gone, and you are a fat storing machine.

It is important to note, this low-level but constant systemic inflammation, PRECEDES insulin/leptin resistance and obesity. Elevated LPS levels, which occur during a Western-style and high-fat diet, initiate all of this.

More bad news: atherosclerosis, heart disease, and stroke are promoted by these same inflammatory pathways. Combined with the increased body fat and insulin resistance, you officially have the perfect ingredients for the dreaded Metabolic Syndrome.

Obviously, this is not what you want your body doing to itself. It is not what you want it doing to you. It is not what you want it doing to your life.

And, it is just a bunch of microscopic bacteria causing all of this devastation. They need to go.

Probiotically Speaking

The most well-known, commercial probiotics are Lactobacillus and Bifidobacterium. They are also among the most common in the body, along with several other really interesting ones which are not commercially available, but we can manipulate with supplementation as you will soon learn.

Unfortunately, Lactobacillus belong to the Firmicutes phylum which is associated with weight gain and obesity. Just a 20% increase in Firmicutes with an equal decrease in Bacteroides results in an increased energy harvest of 150 calories per day in humans. That is equal to 15lbs of fat per year! Modern food processing and the Western style diet promote these negative changes in microbial proportions. Thus, one can plainly see why it can be so difficult to get lean, as well as how easily obesity has become an epidemic.

In addition, probiotic treatment with several Lactobacillus species are directly associated with weight gain, body mass index, obesity, and Type-2 diabetes. They don’t tell you that on the label.

More powerful evidence of the profound effect of the microbiota on body weight and metabolism come from studies on fecal transfer. And, yes, that is exactly what it sounds like – transferring poop from one subject’s intestine to another’s. In twins, transfer of an obese microbiota to lean mice was accompanied by an increase in fat cell formation, fat storage, bodyweight, fat mass, feelings of hunger, food consumption, and a dysbiotic alteration of the Firmicutes:Bacteroides ratio to reflect that of the obese model. On the other side of the coin, transferring the intestinal microbiota from lean donors to obese does the opposite – it fixes all of these things. Obviously, while it highlights the science, doing a fecal transfer is not terribly practical, appetizing, or readily available.

Fortunately, there is good news. While several species and strains of lactobacillus have been found to promote weight gain, several have also been found to protect against it. And, of course, we only used the good ones. Furthermore, Bifidobacterium have shown only positive effects to a remarkable extent.

Caleb No Comments

Shock Therapy™ Ingredients — Part 2

Immediate Action:

Ginsenosides

Adaptogen: Regularizes bodily functions, relieves ailments resulting from physiological stress, and creates balance and homeostasis

Potent, widespread anti-inflammatory

Specifically blocks LPS-induced inflammatory pathways

Zingerone

Anti-inflammatory

Inhibits the all-important LPS

Directly inhibits Toll-like Receptor-4, which links LPS inflammation with reduced insulin and leptin sensitivity

Potent at PPAR-alpha and AMPK comparable to pharmaceutical fibrates, counteracting LPS

Hyperforin

Super potent anti-inflammatory and antioxidant

Suppresses inflammatory prostaglandin PGE(2) biosynthesis better than prescription NSAID indomethacin

Inhibits inflammatory 5-lipoxygenase end product formation comparably to the research standard 5-LO inhibitor zileuton.

Suppressed inflammatory COX-1 end product, 12(S)-hydroxyheptadecatrienoic acid formation with 3-fold more potency than aspirin, while being 18-fold more potent on 5-LO

100 times more potent antioxidant activity than N-acetyl cysteine

Curcumin

Anti-inflammatory action through AMPK

400 times as potent at AMPK as metformin, a Type-2 diabetes medication with the well-known side-effect of fat loss

Protects against LPS-induced inflammation and tissue injury

It reduces the levels of Toll-like Receptor-4 (the insulin and leptin sensitivity killer)

Conclusion

Shock Therapy™ — a first of its kind product which aggressively attacks the genesis of microbiotic dysfunction, including digestive health, metabolic health, and body composition, while promptly and effectively addressing and repairing avenues where this dysfunction manifests.

What to expect: you will have immediate relief of symptoms as well as steady restoration of broken systems, while the bacterial culprits are destroyed, paving the way for SupraBiotic™ and Primer™ to completely transform your gut, your body, and your health.

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Shock Therapy™ Ingredients — Part 1

Shock Therapy™ Ingredients

Anti-Bacterial:

Tyrosol

Potent antibacterial, tailored for the gut

Quorum Sensing: Detects and responds to an increase in bacteria growth and density

Anti-Virulent: Inhibits the production of molecules that aid in colonization of host by pathogenic bacteria

Synergistic with other natural anti-bacterial compounds

Effective over a wide range of bacterial strains

L-Menthol

Very potent and effective against a wide array of bacteria

Disrupts bacterial membrane structure and function, basically making their insides fall out

Renders the bacteria vulnerable to other antibiotics, for a synergistic effect

Curcumin

Similar antibacterial potency as Tyrosol

Inhibits formation of biofilm, the protective shelter required for bacterial growth and survival

Disrupts bacterial cytokinesis, the process by which bacteria reproduce

Hyperforin

Extremely potent, with efficacy specific to the gut due to pharmacokinetics

Effective on wide range of bacteria

Stimulates the body’s natural host defense reactions

Eliminates bacterial breakdown products that would otherwise promote virulence

Zingerone

Complementary and synergistic with the other anti-bacterials

Interferes with several processes of bacterial growth and colonization

Inhibits formation of biofilm, the protective shelter required for bacterial growth and survival

Quorum Sensing: Detects and responds to an increase bacteria growth and density

Anti-Virulent: Inhibits the production of molecules that aid in colonization of host by pathogenic bacteria

Decreases minimum inhibitory concentrations of other anti-bacterials by 2 to 8-fold

All in all, Shock Therapy™ gives you 5 highly effective natural anti-bacterials, working synergistically through nearly every mechanism possible. Invasive, enemy combatant bacteria do not have a chance.

But, just as antibiotics do not get rid of an infection on the first day, they won’t destroy the bad bacteria in your gut immediately. Not to worry, the key ingredients in Shock Therapy™ provide immediate relief and begin healing the gut while the anti-bacterials are getting your renegade microbiota under control.

Caleb No Comments

Shock Therapy™ — Part II

Probiotically Speaking

The most well-known, commercial probiotics are Lactobacillus and Bifidobacterium. They are also among the most common in the body, along with several other really interesting ones which are not commercially available, but we can manipulate with supplementation. Find out more in the SupraBiotic™ and Primer™ write-ups.

Unfortunately, Lactobacillus belong to the Firmicutes phylum which is associated with weight gain and obesity. Just a 20% increase in Firmicutes with an equal decrease in Bacteroides results in an increased energy harvest of 150 calories per day in humans. That is equal to 15lbs of fat per year! Modern food processing and the Western style diet promote these negative changes in microbial proportions. Thus, one can plainly see why it can be so difficult to get lean, as well as how easily obesity has become an epidemic.

In addition, probiotic treatment with several Lactobacillus species are directly associated with weight gain, body mass index, obesity, and Type-2 diabetes. They don’t tell you that on the label.

More powerful evidence of the profound effect of the microbiota on body weight and metabolism come from studies on fecal transfer. And, yes, that is exactly what it sounds like – transferring poop from one subject’s intestine to another’s. In twins, transfer of an obese microbiota to lean mice was accompanied by an increase in fat cell formation, fat storage, bodyweight, fat mass, feelings of hunger, food consumption, and a dysbiotic alteration of the Firmicutes:Bacteroides ratio to reflect that of the obese model. On the other side of the coin, transferring the intestinal microbiota from lean donors to obese does the opposite – it fixes all of these things.

Obviously, while it highlights the science, doing a fecal transfer is not terribly practical, appetizing, or readily available. Fortunately, there is good news. Although several species and strains of Lactobacillus promote weight gain, several protect against it. Furthermore, Bifidobacterium research shows only positive effects to a rather remarkable extent. We can manipulate levels of the good bacteria that are not commercially available, as detailed in the SupraBiotic™ and Primer™ write-ups.

Now, let’s get rid of the bad bacteria already inside you.

Caleb No Comments

Shock Therapy ™ — Part 1

Shock Therapy™
Microbiotic Rebirth™

Gut Feelings
There are trillions of bacteria, living and breeding inside your body, right now. Gross, right. The gut and its microbiome are essentially a massive endocrine organ, controlling and influencing your entire body and brain. You need some of them to survive, but many of them hate you.

For most people, due to genetics and/or diet, the evil ones have gotten the upper hand, attacking you not only with fat gain, but also with whole body inflammation accompanied by damage to insulin sensitivity, cardiovascular and digestive health, the immune system, and even your skin and brain. And, given that all of these trillions of bacteria that call your gut “home” originally came from outside your body – and entered without your permission – it is by far the most important organ in which we can take steps to manipulate and regain control.

Shock Treatment™ is the first step in the process of making yourself king or queen of your own castle. It combines 5 potent, natural antibacterials to seek out and destroy these invaders, freeing your gut kingdom to be repopulated with loyal, benevolent bacterial citizens.
It will ameliorate symptoms, while preparing the gut for a permanent fix, with special emphasis on a lean, healthy body. Be nice to your gut. You’ll thank us later.

Deus Vult!

The Gut-Wrenching Truth

The Western lifestyle (including diet, lack of exercise, and alcohol use) leads to an imbalance of the bacterial composition of the gut. This results in the excess production of inflammatory signals, such as Lipopolysaccharide (LPS), which escape the gut and enter the rest of your body. This leads to general digestive issues and inflammatory bowel syndromes like IBS. While fixing digestive disorders will come along for the ride, our primary focus is going to be on body composition and metabolic health. In other words, we want to make you leaner, protect against diabetes, and help keep you from having a heart attack or stroke.

LPS causes an increase in digestion speed, which leads to less nutrient absorption and feedback signals that tell the brain that it is time to stop eating. But, in the colon, speed is decreased which results in a greater total utilization of caloric energy from your food.

In other words, your brain tells you to keep eating and this leads to excessive fat accumulation from harvesting more calories. This aggravates the cycle further, as overeating and increased adiposity are inflammatory. So, what you have is more inflammation, more dysfunction, greater food intake, greater extraction of food, more fat accumulation, and REPEAT!

The carnage does not end here. Along with this inflammatory state is a disruption in the intestinal barrier. Intestinal permeability is increased and these inflammatory agents spill out. This is often called a “leaky gut”. The biggest culprit here is, once again, LPS.

This goes in conjunction with decrease in activity of brake signals such as short chain fatty acids (SCFAs), PPAR-alpha, and AMPK that act as anti-inflammatories and protect intestinal barrier function.
Once LPS escapes, it is active in the body and brain, just as in the intestine. In the fat tissue, this leads to fat storage. In the brain, it increases appetite, hunger, and food intake. It does so by decreasing both insulin and leptin insensitivity, peripherally and centrally, via Toll-like Receptor-4 (TLR4). At this point, your body fat thermostat is wrecked, your ability to control food intake is gone, and you are a fat storing machine.

It is important to note, this low-level but constant systemic inflammation, PRECEDES insulin/leptin resistance and obesity. Elevated LPS levels, which occur during a Western-style and high-fat diet, initiate all of this.

More bad news: atherosclerosis, heart disease, and stroke are promoted by these same inflammatory pathways. Combined with the increased body fat and insulin resistance, you officially have the perfect ingredients for the dreaded Metabolic Syndrome.

Obviously, this is not what you want your body doing to itself. It is not what you want it doing to you. It is not what you want it doing to your life.

And, it is just a bunch of microscopic bacteria causing all of this devastation.

They need to go.