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SupraBiotic™ — not actually Ingredients

The Best Probiotics That Money Can’t Buy

Unfortunately, several species of bacteria with some of the very best data are not available commercially, due to regulatory issues and well as practical challenges that will not soon be resolved.

Fortunately, there are a myriad of ways to specifically target and increase these strains using methods that ARE available. And, that is exactly what we have done. So, let’s take a look at these novel wonder-bacteria.

Genus Bacteroides

Bacteroides are butyrate and propionate producing. Levels were 6-fold higher in lean vs. obese subjects. It has a negative correlation with fat mass, waist circumference, and energy intake. Bacteroides levels in Type-2 diabetes were only half that of those with normal glucose tolerance. The Firmicutes:Bacteroides ratio was also significantly worse in obese patients, even in comparison with the merely overweight .

Various species in the Bacteroides genus reduced bodyweight and fat gain, triglycerides, and adipocyte volume while improving insulin and leptin sensitivity. It also lowered LPS and other inflammatory signals, while increasing fatty acid oxidation via PPAR-alpha.

Faecalibacterium prausnitzii

Faecalibacterium prausnitzii is butyrate producing and is considered a physiological sensor and marker of human health. It really does not get much more important than that. It is lower in the obese and type-2 diabetics, as well as higher in normal glucose tolerance vs. prediabetic subjects. It reduces inflammatory markers, improves intestinal barrier function, and is sharply decreased in various inflammatory bowel diseases.

Akkermansia muciniphilia

Akkermansia muciniphilia is mucin consuming and butyrate producing. Levels are higher in lean subjects than the general population and decreased in obesity and type-2 diabetes. This species is also inversely correlated to fasting glucose, waist-to-hip ratio, subcutaneous adipocyte diameter, plasma triglyceride levels, visceral adipose tissue mass, and insulin resistance.

Its administration reduced fat mass, adipose tissue inflammation, and enhanced insulin sensitivity. Akkermansia levels are higher in normal glucose tolerance vs. pre-diabetic subjects. It increases intestinal endocannabinoid levels, decreasing inflammatory cytokine production and protecting intestinal barrier function.

Roseburia Species

Roseburia species are butyrate producing. Increased levels are associated with decreased body weight, fat mass, insulin sensitivity, and triglycerides — independent of calorie intake. Higher Roseburia counts are correlated with reduced body weight, improved profile of lipid and obesity related gene expression, along with a normalized inflammatory status. It is also lower in type-2 diabetes and atherosclerosis.

Bifidobacterium adolescentis as Cross-Feeder

As mentioned, the most important contribution of B. adolescentis is to feed other bacteria, specifically the really good but unavailable ones above.

B. adolescentis is superior to other potential cross-feeding Bifidobacterium in that it provides a slow, steady degradation of oligosaccharides for a long, continuous release of substrate for these various bacteria to feed on. It is essentially time-released, allowing acetate feeding, butyrate producing bacteria to grow and thrive throughout the entire length of the gut.

Faecalibacterium prausnitzii is almost fully dependent on acetate, which B. adolescentis supplies. F. prausnitzii converts it to butyrate with 85% efficiency, and its growth is enhanced by co-culture with B. adolescentis. Roseburia also generally requires acetate for growth. B. adolescentis also increases Roseburia and F. prausnitzii via partial breakdown of prebiotic oligosaccharides and carbohydrates, which they can then feed on.

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SupraBiotic™ — Part 1

SupraBiotic™
The Slimming Probiotic™

Gut Feelings

There are trillions of bacteria, living and breeding inside your body, right now. The gut and its microbiome are essentially a massive endocrine organ, controlling and influencing basically your entire body and brain. You need some of them to survive, but many of them hate you.

For most people, due to genetics and/or diet, the evil ones have gotten the upper hand, attacking you with not only fat gain, but whole body inflammation accompanied by damage to insulin sensitivity, cardiovascular and digestive health, the immune system, and even your skin and brain. And, given that all of these trillions of bacteria that call your gut “home” originally came from outside your body – and entered without your permission – it is by far the most important organ in which we can take steps to manipulate and regain control.

SupraBiotic™ combines 6 probiotic strains, over 80 billion colony forming units, with an unrivalled auxiliary formula, optimized to turn the bacterial milieu of your gut into a mean, lean body machine.

You have sought out and destroyed these invaders with Shock Therapy™, freeing the kingdom of your gut. Now, repopulate it with loyal, benevolent bacterial citizens with SupraBiotic™
Deus Vult!

The Gut-Wrenching Truth

The Western lifestyle (including diet, lack of exercise, and alcohol use) leads to an imbalance of the bacterial composition of the gut. This results in the excess production of inflammatory signals, such as Lipopolysaccharide (LPS), which escape the gut and enter the rest of your body. This leads to general digestive issues and inflammatory bowel syndromes like IBS. While fixing digestive disorders will come along for the ride, our primary focus is going to be on body composition and metabolic health. In other words, we want to make you leaner, protect against diabetes, and help keep you from having a heart attack or stroke.

LPS causes an increase in digestion speed, which leads to less nutrient absorption and feedback signals that tell the brain that it is time to stop eating. But, in the colon, speed is decreased which results in a greater total utilization of caloric energy from your food.

In other words, your brain tells you to keep eating and this leads to excessive fat accumulation from harvesting more calories. This aggravates the cycle further, as overeating and increased adiposity are inflammatory. So, what you have is more inflammation, more dysfunction, greater food intake, greater extraction of food, more fat accumulation, and REPEAT!

The carnage does not end here. Along with this inflammatory state is a disruption in the intestinal barrier. Intestinal permeability is increased and these inflammatory agents spill out. This is often called a “leaky gut”. The biggest culprit here is, once again, LPS.

This goes in conjunction with decrease in activity of brake signals such as short chain fatty acids (SCFAs), PPAR-alpha, and AMPK that act as anti-inflammatories and protect intestinal barrier function.

Once LPS escapes, it is active in the body and brain, just as in the intestine. In the fat tissue, this leads to fat storage. In the brain, it increases appetite, hunger, and food intake. It does so by decreasing both insulin and leptin insensitivity, peripherally and centrally, via Toll-like Receptor-4 (TLR4). At this point, your body fat thermostat is wrecked, your ability to control food intake is gone, and you are a fat storing machine.

It is important to note, this low-level but constant systemic inflammation, PRECEDES insulin/leptin resistance and obesity. Elevated LPS levels, which occur during a Western-style and high-fat diet, initiate all of this.

More bad news: atherosclerosis, heart disease, and stroke are promoted by these same inflammatory pathways. Combined with the increased body fat and insulin resistance, you officially have the perfect ingredients for the dreaded Metabolic Syndrome.

Obviously, this is not what you want your body doing to itself. It is not what you want it doing to you. It is not what you want it doing to your life.

And, it is just a bunch of microscopic bacteria causing all of this devastation. They need to go.

Probiotically Speaking

The most well-known, commercial probiotics are Lactobacillus and Bifidobacterium. They are also among the most common in the body, along with several other really interesting ones which are not commercially available, but we can manipulate with supplementation as you will soon learn.

Unfortunately, Lactobacillus belong to the Firmicutes phylum which is associated with weight gain and obesity. Just a 20% increase in Firmicutes with an equal decrease in Bacteroides results in an increased energy harvest of 150 calories per day in humans. That is equal to 15lbs of fat per year! Modern food processing and the Western style diet promote these negative changes in microbial proportions. Thus, one can plainly see why it can be so difficult to get lean, as well as how easily obesity has become an epidemic.

In addition, probiotic treatment with several Lactobacillus species are directly associated with weight gain, body mass index, obesity, and Type-2 diabetes. They don’t tell you that on the label.

More powerful evidence of the profound effect of the microbiota on body weight and metabolism come from studies on fecal transfer. And, yes, that is exactly what it sounds like – transferring poop from one subject’s intestine to another’s. In twins, transfer of an obese microbiota to lean mice was accompanied by an increase in fat cell formation, fat storage, bodyweight, fat mass, feelings of hunger, food consumption, and a dysbiotic alteration of the Firmicutes:Bacteroides ratio to reflect that of the obese model. On the other side of the coin, transferring the intestinal microbiota from lean donors to obese does the opposite – it fixes all of these things. Obviously, while it highlights the science, doing a fecal transfer is not terribly practical, appetizing, or readily available.

Fortunately, there is good news. While several species and strains of lactobacillus have been found to promote weight gain, several have also been found to protect against it. And, of course, we only used the good ones. Furthermore, Bifidobacterium have shown only positive effects to a remarkable extent.

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Shock Therapy™ Ingredients — Part 2

Immediate Action:

Ginsenosides

Adaptogen: Regularizes bodily functions, relieves ailments resulting from physiological stress, and creates balance and homeostasis

Potent, widespread anti-inflammatory

Specifically blocks LPS-induced inflammatory pathways

Zingerone

Anti-inflammatory

Inhibits the all-important LPS

Directly inhibits Toll-like Receptor-4, which links LPS inflammation with reduced insulin and leptin sensitivity

Potent at PPAR-alpha and AMPK comparable to pharmaceutical fibrates, counteracting LPS

Hyperforin

Super potent anti-inflammatory and antioxidant

Suppresses inflammatory prostaglandin PGE(2) biosynthesis better than prescription NSAID indomethacin

Inhibits inflammatory 5-lipoxygenase end product formation comparably to the research standard 5-LO inhibitor zileuton.

Suppressed inflammatory COX-1 end product, 12(S)-hydroxyheptadecatrienoic acid formation with 3-fold more potency than aspirin, while being 18-fold more potent on 5-LO

100 times more potent antioxidant activity than N-acetyl cysteine

Curcumin

Anti-inflammatory action through AMPK

400 times as potent at AMPK as metformin, a Type-2 diabetes medication with the well-known side-effect of fat loss

Protects against LPS-induced inflammation and tissue injury

It reduces the levels of Toll-like Receptor-4 (the insulin and leptin sensitivity killer)

Conclusion

Shock Therapy™ — a first of its kind product which aggressively attacks the genesis of microbiotic dysfunction, including digestive health, metabolic health, and body composition, while promptly and effectively addressing and repairing avenues where this dysfunction manifests.

What to expect: you will have immediate relief of symptoms as well as steady restoration of broken systems, while the bacterial culprits are destroyed, paving the way for SupraBiotic™ and Primer™ to completely transform your gut, your body, and your health.

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Shock Therapy™ Ingredients — Part 1

Shock Therapy™ Ingredients

Anti-Bacterial:

Tyrosol

Potent antibacterial, tailored for the gut

Quorum Sensing: Detects and responds to an increase in bacteria growth and density

Anti-Virulent: Inhibits the production of molecules that aid in colonization of host by pathogenic bacteria

Synergistic with other natural anti-bacterial compounds

Effective over a wide range of bacterial strains

L-Menthol

Very potent and effective against a wide array of bacteria

Disrupts bacterial membrane structure and function, basically making their insides fall out

Renders the bacteria vulnerable to other antibiotics, for a synergistic effect

Curcumin

Similar antibacterial potency as Tyrosol

Inhibits formation of biofilm, the protective shelter required for bacterial growth and survival

Disrupts bacterial cytokinesis, the process by which bacteria reproduce

Hyperforin

Extremely potent, with efficacy specific to the gut due to pharmacokinetics

Effective on wide range of bacteria

Stimulates the body’s natural host defense reactions

Eliminates bacterial breakdown products that would otherwise promote virulence

Zingerone

Complementary and synergistic with the other anti-bacterials

Interferes with several processes of bacterial growth and colonization

Inhibits formation of biofilm, the protective shelter required for bacterial growth and survival

Quorum Sensing: Detects and responds to an increase bacteria growth and density

Anti-Virulent: Inhibits the production of molecules that aid in colonization of host by pathogenic bacteria

Decreases minimum inhibitory concentrations of other anti-bacterials by 2 to 8-fold

All in all, Shock Therapy™ gives you 5 highly effective natural anti-bacterials, working synergistically through nearly every mechanism possible. Invasive, enemy combatant bacteria do not have a chance.

But, just as antibiotics do not get rid of an infection on the first day, they won’t destroy the bad bacteria in your gut immediately. Not to worry, the key ingredients in Shock Therapy™ provide immediate relief and begin healing the gut while the anti-bacterials are getting your renegade microbiota under control.

Caleb No Comments

Shock Therapy™ — Part II

Probiotically Speaking

The most well-known, commercial probiotics are Lactobacillus and Bifidobacterium. They are also among the most common in the body, along with several other really interesting ones which are not commercially available, but we can manipulate with supplementation. Find out more in the SupraBiotic™ and Primer™ write-ups.

Unfortunately, Lactobacillus belong to the Firmicutes phylum which is associated with weight gain and obesity. Just a 20% increase in Firmicutes with an equal decrease in Bacteroides results in an increased energy harvest of 150 calories per day in humans. That is equal to 15lbs of fat per year! Modern food processing and the Western style diet promote these negative changes in microbial proportions. Thus, one can plainly see why it can be so difficult to get lean, as well as how easily obesity has become an epidemic.

In addition, probiotic treatment with several Lactobacillus species are directly associated with weight gain, body mass index, obesity, and Type-2 diabetes. They don’t tell you that on the label.

More powerful evidence of the profound effect of the microbiota on body weight and metabolism come from studies on fecal transfer. And, yes, that is exactly what it sounds like – transferring poop from one subject’s intestine to another’s. In twins, transfer of an obese microbiota to lean mice was accompanied by an increase in fat cell formation, fat storage, bodyweight, fat mass, feelings of hunger, food consumption, and a dysbiotic alteration of the Firmicutes:Bacteroides ratio to reflect that of the obese model. On the other side of the coin, transferring the intestinal microbiota from lean donors to obese does the opposite – it fixes all of these things.

Obviously, while it highlights the science, doing a fecal transfer is not terribly practical, appetizing, or readily available. Fortunately, there is good news. Although several species and strains of Lactobacillus promote weight gain, several protect against it. Furthermore, Bifidobacterium research shows only positive effects to a rather remarkable extent. We can manipulate levels of the good bacteria that are not commercially available, as detailed in the SupraBiotic™ and Primer™ write-ups.

Now, let’s get rid of the bad bacteria already inside you.

Caleb No Comments

Shock Therapy ™ — Part 1

Shock Therapy™
Microbiotic Rebirth™

Gut Feelings
There are trillions of bacteria, living and breeding inside your body, right now. Gross, right. The gut and its microbiome are essentially a massive endocrine organ, controlling and influencing your entire body and brain. You need some of them to survive, but many of them hate you.

For most people, due to genetics and/or diet, the evil ones have gotten the upper hand, attacking you not only with fat gain, but also with whole body inflammation accompanied by damage to insulin sensitivity, cardiovascular and digestive health, the immune system, and even your skin and brain. And, given that all of these trillions of bacteria that call your gut “home” originally came from outside your body – and entered without your permission – it is by far the most important organ in which we can take steps to manipulate and regain control.

Shock Treatment™ is the first step in the process of making yourself king or queen of your own castle. It combines 5 potent, natural antibacterials to seek out and destroy these invaders, freeing your gut kingdom to be repopulated with loyal, benevolent bacterial citizens.
It will ameliorate symptoms, while preparing the gut for a permanent fix, with special emphasis on a lean, healthy body. Be nice to your gut. You’ll thank us later.

Deus Vult!

The Gut-Wrenching Truth

The Western lifestyle (including diet, lack of exercise, and alcohol use) leads to an imbalance of the bacterial composition of the gut. This results in the excess production of inflammatory signals, such as Lipopolysaccharide (LPS), which escape the gut and enter the rest of your body. This leads to general digestive issues and inflammatory bowel syndromes like IBS. While fixing digestive disorders will come along for the ride, our primary focus is going to be on body composition and metabolic health. In other words, we want to make you leaner, protect against diabetes, and help keep you from having a heart attack or stroke.

LPS causes an increase in digestion speed, which leads to less nutrient absorption and feedback signals that tell the brain that it is time to stop eating. But, in the colon, speed is decreased which results in a greater total utilization of caloric energy from your food.

In other words, your brain tells you to keep eating and this leads to excessive fat accumulation from harvesting more calories. This aggravates the cycle further, as overeating and increased adiposity are inflammatory. So, what you have is more inflammation, more dysfunction, greater food intake, greater extraction of food, more fat accumulation, and REPEAT!

The carnage does not end here. Along with this inflammatory state is a disruption in the intestinal barrier. Intestinal permeability is increased and these inflammatory agents spill out. This is often called a “leaky gut”. The biggest culprit here is, once again, LPS.

This goes in conjunction with decrease in activity of brake signals such as short chain fatty acids (SCFAs), PPAR-alpha, and AMPK that act as anti-inflammatories and protect intestinal barrier function.
Once LPS escapes, it is active in the body and brain, just as in the intestine. In the fat tissue, this leads to fat storage. In the brain, it increases appetite, hunger, and food intake. It does so by decreasing both insulin and leptin insensitivity, peripherally and centrally, via Toll-like Receptor-4 (TLR4). At this point, your body fat thermostat is wrecked, your ability to control food intake is gone, and you are a fat storing machine.

It is important to note, this low-level but constant systemic inflammation, PRECEDES insulin/leptin resistance and obesity. Elevated LPS levels, which occur during a Western-style and high-fat diet, initiate all of this.

More bad news: atherosclerosis, heart disease, and stroke are promoted by these same inflammatory pathways. Combined with the increased body fat and insulin resistance, you officially have the perfect ingredients for the dreaded Metabolic Syndrome.

Obviously, this is not what you want your body doing to itself. It is not what you want it doing to you. It is not what you want it doing to your life.

And, it is just a bunch of microscopic bacteria causing all of this devastation.

They need to go.