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Primer™
Microbiomic Superfuel™

Gut Feelings
There are trillions of bacteria, living and breeding inside your body, right now. The gut and its microbiome are essentially a massive endocrine organ, controlling and influencing basically your entire body and brain. You need some of them to survive, but many of them hate you.

For most people, due to genetics and/or diet, the evil ones have gotten the upper hand, attacking you with not only fat gain, but whole body inflammation accompanied by damage to insulin sensitivity, cardiovascular and digestive health, the immune system, and even your skin and brain. And, given that all of these trillions of bacteria that call your gut “home” originally came from outside your body – and entered without your permission – it is by far the most important organ in which we can take steps to manipulate and regain control.

You have sought out and destroyed these invaders with Shock Therapy™, freeing the kingdom of your gut. You are repopulating it with loyal, benevolent bacterial citizens with SupraBiotic™. But, you must feed, protect, and nurture them.

Primer™ provides a gourmet buffet of prebiotic dishes specifically prepared to the needs and tastes of the most beneficial probiotic bacteria, along with the materials to rebuild, fortify, and make impregnable, the castle walls that are the intestinal barrier.

Deus Vult!

The Gut-Wrenching Truth

The Western lifestyle (including diet, lack of exercise, and alcohol use) leads to an imbalance of the bacterial composition of the gut. This results in the excess production of inflammatory signals, such as Lipopolysaccharide (LPS), which escape the gut and enter the rest of your body. This leads to general digestive issues and inflammatory bowel syndromes like IBS. While fixing digestive disorders will come along for the ride, our primary focus is going to be on body composition and metabolic health. In other words, we want to make you leaner, protect against diabetes, and help keep you from having a heart attack or stroke.

LPS causes an increase in digestion speed, which leads to less nutrient absorption and feedback signals that tell the brain that it is time to stop eating. But, in the colon, speed is decreased which results in a greater total utilization of caloric energy from your food.

In other words, your brain tells you to keep eating and this leads to excessive fat accumulation from harvesting more calories. This aggravates the cycle further, as overeating and increased adiposity are inflammatory. So, what you have is more inflammation, more dysfunction, greater food intake, greater extraction of food, more fat accumulation, and REPEAT!

The carnage does not end here. Along with this inflammatory state is a disruption in the intestinal barrier. Intestinal permeability is increased and these inflammatory agents spill out. This is often called a “leaky gut”. The biggest culprit here is, once again, LPS.

This goes in conjunction with decrease in activity of brake signals such as short chain fatty acids (SCFAs), PPAR-alpha, and AMPK that act as anti-inflammatories and protect intestinal barrier function.

Once LPS escapes, it is active in the body and brain, just as in the intestine. In the fat tissue, this leads to fat storage. In the brain, it increases appetite, hunger, and food intake. It does so by decreasing both insulin and leptin insensitivity, peripherally and centrally, via Toll-like Receptor-4 (TLR4). At this point, your body fat thermostat is wrecked, your ability to control food intake is gone, and you are a fat storing machine.

It is important to note, this low-level but constant systemic inflammation, PRECEDES insulin/leptin resistance and obesity. Elevated LPS levels, which occur during a Western-style and high-fat diet, initiate all of this.

More bad news: atherosclerosis, heart disease, and stroke are promoted by these same inflammatory pathways. Combined with the increased body fat and insulin resistance, you officially have the perfect ingredients for the dreaded Metabolic Syndrome.

Obviously, this is not what you want your body doing to itself. It is not what you want it doing to you. It is not what you want it doing to your life.

And, it is just a bunch of microscopic bacteria causing all of this devastation. They need to go.

Probiotically Speaking

The most well-known, commercial probiotics are Lactobacillus and Bifidobacterium. They are also among the most common in the body, along with several other really interesting ones which are not commercially available, but we can manipulate with supplementation as you will soon learn.

Unfortunately, Lactobacillus belong to the Firmicutes phylum which is associated with weight gain and obesity. Just a 20% increase in Firmicutes with an equal decrease in Bacteroides results in an increased energy harvest of 150 calories per day in humans. That is equal to 15lbs of fat per year! Modern food processing and the Western style diet promote these negative changes in microbial proportions. Thus, one can plainly see why it can be so difficult to get lean, as well as how easily obesity has become an epidemic.

In addition, probiotic treatment with several Lactobacillus species are directly associated with weight gain, body mass index, obesity, and Type-2 diabetes. They don’t tell you that on the label.

More powerful evidence of the profound effect of the microbiota on body weight and metabolism come from studies on fecal transfer. And, yes, that is exactly what it sounds like – transferring poop from one subject’s intestine to another’s. In twins, transfer of an obese microbiota to lean mice was accompanied by an increase in fat cell formation, fat storage, bodyweight, fat mass, feelings of hunger, food consumption, and a dysbiotic alteration of the Firmicutes:Bacteroides ratio to reflect that of the obese model. On the other side of the coin, transferring the intestinal microbiota from lean donors to obese does the opposite – it fixes all of these things. Obviously, while it highlights the science, doing a fecal transfer is not terribly practical, appetizing, or readily available.

Fortunately, there is good news. While several species and strains of lactobacillus have been found to promote weight gain, several have also been found to protect against it. And, of course, we only used the good ones. Furthermore, Bifidobacterium have shown only positive effects to a remarkable extent.

So, let’s get to it.

You may have noticed that almost no probiotic formulas contain just a single species of bacteria, nowadays. And, if you did not, I will just say that it is for a good reason. They work better in combination. Microbial diversity is good. Essentially, a diverse gut is a healthy gut. This applies to the prebiotics that feed them. You need a variety of prebiotics to grow a variety of probiotic bacterial species.

However, you do not to be randomly feeding every single species and strain inside of you. It needs to be done rationally. You want the good ones to gorge themselves, and the bad ones to have to go hungry.

Another benefit of prebiotic combinations is by providing precursors to promote cross-feeding. This is when fermentation by one bacterial strain produces metabolites that others use for fuel, as we will discuss in a bit.

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