Par Deus No Comments

The Best Probiotics That Money Can’t Buy

Unfortunately, several species of bacteria with some of the very best data are not available commercially, due to regulatory issues and well as practical challenges that will not soon be resolved.

Fortunately, there are a myriad of ways to specifically target and increase these strains using methods that ARE available. And, that is exactly what we have done. So, let’s take a look at these novel wonder-bacteria.

Genus Bacteroides

Bacteroides are butyrate and propionate producing. Levels were 6-fold higher in lean vs. obese subjects. It has a negative correlation with fat mass, waist circumference, and energy intake. Bacteroides levels in Type-2 diabetes were only half that of those with normal glucose tolerance. The Firmicutes:Bacteroides ratio was also significantly worse in obese patients, even in comparison with the merely overweight .

Various species in the Bacteroides genus reduced bodyweight and fat gain, triglycerides, and adipocyte volume while improving insulin and leptin sensitivity. It also lowered LPS and other inflammatory signals, while increasing fatty acid oxidation via PPAR-alpha.

Faecalibacterium prausnitzii

Faecalibacterium prausnitzii is butyrate producing and is considered a physiological sensor and marker of human health. It really does not get much more important than that. It is lower in the obese and type-2 diabetics, as well as higher in normal glucose tolerance vs. prediabetic subjects. It reduces inflammatory markers, improves intestinal barrier function, and is sharply decreased in various inflammatory bowel diseases.

Akkermansia muciniphilia

Akkermansia muciniphilia is mucin consuming and butyrate producing. Levels are higher in lean subjects than the general population and decreased in obesity and type-2 diabetes. This species is also inversely correlated to fasting glucose, waist-to-hip ratio, subcutaneous adipocyte diameter, plasma triglyceride levels, visceral adipose tissue mass, and insulin resistance.

Its administration reduced fat mass, adipose tissue inflammation, and enhanced insulin sensitivity. Akkermansia levels are higher in normal glucose tolerance vs. pre-diabetic subjects. It increases intestinal endocannabinoid levels, decreasing inflammatory cytokine production and protecting intestinal barrier function.

Roseburia Species

Roseburia species are butyrate producing. Increased levels are associated with decreased body weight, fat mass, insulin sensitivity, and triglycerides — independent of calorie intake. Higher Roseburia counts are correlated with reduced body weight, improved profile of lipid and obesity related gene expression, along with a normalized inflammatory status. It is also lower in type-2 diabetes and atherosclerosis.

Bifidobacterium adolescentis as Cross-Feeder

As mentioned, the most important contribution of B. adolescentis is to feed other bacteria, specifically the really good but unavailable ones above.

B. adolescentis is superior to other potential cross-feeding Bifidobacterium in that it provides a slow, steady degradation of oligosaccharides for a long, continuous release of substrate for these various bacteria to feed on. It is essentially time-released, allowing acetate feeding, butyrate producing bacteria to grow and thrive throughout the entire length of the gut.

Faecalibacterium prausnitzii is almost fully dependent on acetate, which B. adolescentis supplies. F. prausnitzii converts it to butyrate with 85% efficiency, and its growth is enhanced by co-culture with B. adolescentis. Roseburia also generally requires acetate for growth. B. adolescentis also increases Roseburia and F. prausnitzii via partial breakdown of prebiotic oligosaccharides and carbohydrates, which they can then feed on.

Leave a Reply

Your email address will not be published. Required fields are marked *